Our current scientific interests encompasses both basic and clinical research, including the origins, mechanisms and maintenance of ionic and volume homeostasis in the CNS and the role of extrasynaptic transmission and glial cells in physiological and pathological states. We are particularly interested in the mechanisms and treatment of brain and spinal cord injury. We study the migration and fate of embryonic and adult stem cells using MRI and iron-oxide nanoparticles and explores the use of hydrogels and nanofibers as tissue bridges and 3D stem cell carriers after CNS injury, as well as the differentiation and role of stem cells in the rescue and replacement of damaged tissue. We are currently leading several clinical studies, including a Phase I/II study in patients with spinal cord injury as well as ongoing clinical studies of patients with ALS and ischemic leg injury.
Forostyak, S., Homola, A., Turnovcova, K., Svitil, P., Jendelova, P., & Sykova, E. (2014). Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS. Stem Cells, 32(12), 3163-3172.
Amemori T., Romanyuk N., Jendelova P., Herynek V., Turnovcova K., Prochazka P., Kapcalova M., Cocks G., Price J., Sykova E. (2013) Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat. Stem Cell Res. Ther., 4(3): 68.
Kubinová Š. and Syková E. (2012) Biomaterials combined with cell therapy for treatment of spinal cord injury. Regen. Med., 7(2): 207-224.
Hejcl A., Sedý J., Kapcalová M., Arboleda Toro D., Amemori T., Likavčanová-Mašínová K., Lesný P., Krumbholcová E., Přádný M., Michálek J., Burian M., Hájek M., Jendelová P., Sykova E. (2010) HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. Stem Cells Dev., 19: 1535-46.
Syková E. and Nicholson C. (2008) Diffusion in brain extracellular space. Physiol Rev., 88: 1277-1340.
2011 Elected member of The Learned Society of the Czech Republic
2009 Honorary Membership of the Czech Medical Society of J.E. Purkyně
2009 Honorary Membership of the Czech Neuroscience Society
2009 Best publication, Czech Medical Society of J.E. Purkyně
2008 Medal of Jan Trapel
2005 Jansen-Cilag Foundation Award
2004 Elected Fellow of Czech Medical Academy (FCMA)
2004 "Lady pro" Award
2003 Purkynje Medal AS CR
2002 Elected member of European Academy of Sciences
2000 Elected member of European DANA Aliance
1999 Elected member of Academia Europea
1997 Janssen-Cilag Award
1997 Prize of Czech Academy of Sciences
1994 Prize of Czech Medical Society of J.E. Purkyně
1993 Prize of Czech Neuroscience Society
1992 Prize of Czech Medical Society of J.E. Purkyně
1984 Prize of Czechoslovak Physiological Society
1982 Prize of Czechoslovak Academy of Sciences
1976 Awards of Czechoslovak Academy of Sciences (and 1978)