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Centre for Integrative Physiology
University of Edinburgh
Hugh Robson Building
George Square
EH8 9XD - Edinburgh
UK

+44 131 650 3113



Job opportunities

Dr Ian Duguid
Neuroscience
Centre for Neuroregeneration University of Edinburgh

Research Area

Publications

Mathy A, Ho SS, Davie JT, Duguid IC, Clark BA, Häusser M (2009). Encoding of oscillations by axonal bursts in inferior olive neurons. Neuron 62 (3): 388-399.

 

Rancz EA*, Ishikawa T*, Duguid IC*, Chadderton P*, Mahon S and Häusser M (2007). High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature 450 (7173):1245-8.

 

Duguid IC, Pankratov Y, Moss GW and Smart TG (2007). Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. Journal of Neuroscience 27(46), 12464-12474.

 

Duguid IC and Sjostrom PJ (2006). Novel presynaptic mechanisms for coincidence detection in synaptic plasticity. Current Opinion in Neurobiology 16(3), 312-22.

 

Harvey VL, Duguid IC, Krasel C and Stephens GJ (2006). Evidence that GABA rho subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells.
Journal of Physiology (Lond.) 15;577(Pt 1), 127-39.

 

Rees MI, Harvey K, Pearce BR, Chung SK, Duguid IC, Thomas P, Beatty S, Graham GE, Armstrong L, Shiang R, Abbott KJ, Zuberi SM, Stephenson JB, Owen MJ, Tijssen MA, van den Maagdenberg AM, Smart TG, Supplisson S, Harvey RJ (2006). Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease. Nature Genetics 38(7), 801-6.

 

Duguid IC and Smart TG (2004). Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneurone-Purkinje cell synapses. Nature Neuroscience 7(5), 525-533.

 

Harvey K, Duguid IC, Alldred M, Beatty SE, Ward H, Keep NH, Lingenfelter SE, Pearce BR, Lundgren J, Owen MJ, Smart TG, Lüscher B, Rees MI and Harvey RJ (2004). The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. Journal of Neuroscience 24(25), 5816-5826.

 

Duguid IC and Smart TG (2003). Regulation of cerebellar inhibitory synaptic plasticity by presynaptic NMDA receptors. Journal of Physiology. 547P PC29.

 

Rees MI, Harvey K, Ward H, Evans L, Duguid IC, Hsu CC, Coleman SL, Miller J, Baer K, Waldvogel HJ, Gibbon F, Smart TG, Owen MJ, Harvey RJ and Snell RG (2003). Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in Hyperekplexia. The Journal of Biological Chemistry, 278 (27), 24688-24696.

 

Dunne EL, Hosie AM, Wooltorton JRA, Duguid IC, Harvey K, Moss SJ, Harvey RJ and Smart TG (2002). An N-terminal histidine regulate Zn2+ inhibition on the murine GABA receptor b3 subunit. British Journal of Pharmacology, 137, 29-38.

 

BOOK CHAPTERS

 

Duguid IC and Smart TG (2008). Presynaptic NMDA receptors. In, ‘Biology of the NMDA receptor’ – Frontiers in Neuroscience, Taylor & Francis CRC press, Chapter 14, 311-321.

 


Technical Expertise

·      In vivo whole-cell patch clamp electrophysiology

·      In vitro slice electrophysiology

·      Confocal and 2-photon microscopy

·      Rodent behaviour and learning