Szigony u. 43



1083 - Budapest
Hungary



szabadicsj@koki.hu

Job opportunities

The interaction of neuronal activities in the CA3 area of the hippocampus provided by mossy fibres (the axon of dentate gyrus granule cells) and auto-associative networks of local pyramidal cells is essential in the ability to distinguish novel situations from previously acquired memories. The mossy fibres introduce certain novel information about the environment in the CA3 network, and this incoming excitation is correlated with previously acquired memories that are represented by the interconnected synaptic network of local pyramidal cells. However, the underlying neuronal mechanisms of this interaction are not well understood. Taking advantage of various cutting-edge experimental techniques (in particular with a novel method that allows the study of monosynaptic connections between DG and CA3 neurons by directly recording from presynaptic mossy fibre terminals), the new research group will elucidate underlying cellular mechanisms of the DG-CA3 interface.

Szabadics J, Soltesz I. (2009) Functional specificity of mossy fiber innervation of GABAergic cells in the hippocampus. J Neurosci 29: 4239 - 4251

Szabadics J, Tamás G, Soltesz I (2007) Different transmitter transients underlie presynaptic cell type specificity of GABA_A,slow and GABA_A,fast. PNAS 104: 14831-14836.

Szabadics J, Varga C, Molnár G, Oláh S, Barzó P, Tamás G (2006) Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science 311: 233-235.

Tamás G, Lőrincz A, Simon A, Szabadics J (2003) Identified sources and targets of slow inhibition in the neocortex. Science 299: 1902-1905.

Szabadics J, Lőrincz A, Tamás G (2001) β and γ frequency synchronization by dendritic GABAergic synapses and gap junctions in a network of cortical interneurons. J Neurosci 21: 5824-5831.