Institute of Molecular Biology and Biotechnology
Foundation for Research and Technology - Hellas
Vassilika Vouton, PO Box 1385

71110 - Heraklion, Crete
Greece

+30-(0)2810-391066(5)
+30-(0)2810-391067
tavernarakis@imbb.forth.gr

Job opportunities

We aim to elucidate the molecular mechanisms underlying sensory transduction and integration that forms the basis of learning and memory in the nematode C. elegans. DEG/ENaC ion channels have been identified in nematodes, snails, flies and vertebrates including humans, where they serve diverse functions such as ion homeostasis and sensory transduction. Members of the acid-sensing subgroup of DEG/ENaC ion channels (termed ASICs) have been implicated in synaptic plasticity, learning and memory in mammals.

We find that ASIC-1, a novel nematode DEG/ENaC protein and a close homologue of mammalian ASIC is required for conditioning to several chemical attractants, while it is dispensable for chemotaxis. Consistently, this gene is also required for associating the presence of food with the rearing temperature. Our observations indicate that DEG/ENaCs contribute to the capacity of the animal for associative learning. Therefore, ASIC roles in associative learning and memory are conserved from nematodes to mammals, thus, making C. elegans an attractive model in which to dissect the relevant mechanisms.

Please see also: http://www.imbb.forth.gr/worms