Karolinska Institutet
Department Neuroscience
CoE in Developmental Biology for Regenerative Medicine (DBRM)
Laboratory of Molecular Neurodevelopment
SE17177 - Stockholm
Sweden

+46 8-524 874 77
+46 8-333 864
ola.hermanson@ki.se

Job opportunities

The group studies the molecular mechanisms governing the development of neural cells and neural circuits involved in stress, in particular the forebrain and hypothalamus.
We use neural stem cells in vitro and transgenic animals in vivo to elucidate the molecular genetics and transcriptional mechanisms downstream of growth factors and morphogens, that regulate differentiation and development of these neurons.
The work focuses on transcriptional repression and de-repression, with a special interest in histone modifications, e.g. acetylation, the influence of histone control on neural development, and the integration of environmental signals with chromatin.

Joseph B., Andersson E.R., Vlachos P., Södersten, E. Liu L., Teixeira A.I., and Hermanson O. (2009) p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells. Cell Death Differ., in press.

Andersson T., Södersten E., Duckworth J.K., Cascante A., Fritz N., Sacchetti P., Cervenka I., Bryja V., and Hermanson O. (2009) CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells. J. Biol. Chem. 284, 3672-3681.

Hermanson O. (2008) Stem cells have different needs for REST. PLoS Biol. 6, e271.

Hajji N., Wallenborg K., Vlachos P., Nyman U., Hermanson O., and Joseph, B. (2008) Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. Oncogene 27, 3134-3144.

Jepsen K., Solum D., Zhou T., McEvilly R.J., Kim H.J., Glass C.K., Hermanson O., and Rosenfeld M.G. (2007) SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450, 415-419.

Chromatin immunoprecipitation techniques in neural and other stem cells