Karolinska Institutet
Stockholm Nobel Institute for Neurophysiology
Department Neuroscience
DBRM
17177 - Stockholm
Sweden

+46-8-52487849
+46-8-325861
oleg.shupliakov@ki.se
oleshu

Job opportunities

The research goal of the group is to clarify molecular mechanisms controlling membrane trafficing events during endocytosis with a focus on neuronal cells. The main focucs is on the analysis of functions of multidomain scaffolding molecules, which control the organization of endocytic sites and fission of vesicles and endosomes from the plasma membrane.

Shupliakov, O. (2009) The synaptic vesicle cycle: a source of endocytic proteins during neurotransmitter release. Neuroscience 158: 204-210.

Owe, S.G., Jensen, V., Evergren, E., Ruiz, A., Shupliakov, O., Kullmann, D.M., Storm-Mathisen, J., Walaas, S.I., Hvalby, Ø., Bergersen, L.H. (2009) Synapsin- and actin-dependent frequency enhancement in mouse hippocampal mossy fiber synapses. Cereb Cortex. 19: 511-523.

Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Naldini, L., Barnabé-Heider, F., Yeung, M. S. Y., Naldini, L., Honjo, T., Shupliakov, O., Cassidy, R.M., Lindvall, O., Frisén, J. (2009) Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nature Neurosci. 12: 259-267.

Wallis, K., Sjögren, M., van Hogerlinden, M., Silberberg, G,. Fisahn, A., Nordström, K., Larsson, L., Westerblad, H., Morreale de Escobar, G., Shupliakov, O., Vennström, B. (2008) Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha1. J Neurosci. 28: 1904- 1915.

Andersson, F., Jakobsson, J., Löw, P., Shupliakov, O., Brodin, L. (2008) Perturbation of syndapin/PACSIN impairs synaptic vesicle recycling evoked by intense stimulation. J Neurosci. 28: 3925-3933.

Meletis, K., Carlén, M., Barnabé-Heiden, F., Evergren, E., Tomilin, N., Shupliakov, O., Frisén, J. (2008) Identification of neural stem cells that contribute to scar formation after spinal cord injury. PLos Biology 6: e182.

Jakobsson, J., Gad, H., Andersson, F., Löw, P., Shupliakov, O., Brodin, L. (2008) Role of epsin 1 in synaptic vesicle endocytosis. Proc. Natl. Acad. Sci. USA. 105: 6445-6450.

Koh, T-W., Korolchuk, V., Wairkar, Y.P., Jiao, W., Evergren, E., Pan, H., Zhou, Y., Venken, K. J.T., Shupliakov, O., Robinson, I.M., O’Kane, C.J., Bellen, H. J. (2007) Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J. Cell Biol. 178: 309-322.

3D-electron microscopy, electrophysiology, cellular imaging, molecular biology