The Brain and Mind Institute Lausanne
Laboratoire de mécanismes synaptiques
Bâtiment SV 2808, Station 19

CH-1015 - Lausanne
Switzerland

+41 21 6935364
+41 21 693 1897
ralf.schneggenburger@epfl.ch

Job opportunities

The group works on synaptic transmission, Ca2+ buffering, and Ca2+ extrusion in nerve terminals in order to study short-term plasticity of transmitter release.
By analyzing intracellular signaling cascades involved in the modulation of transmitter release it is expected to gain insight into the regulation of synaptic connectivity between neurons.

Kochubey, O., and Schneggenburger, R. (2011). Synaptotagmin increases the dynamic range of synapses by driving Ca2+ - evoked release and by clamping a near-linear remaining Ca2+ sensor. Neuron 69: 736 -748.

Han, Y., Kaeser, P. S., Südhof, T. C., and Schneggenburger, R. (2011). RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone. Neuron 69, 304-316.

Beurg, M., Michalski, N., Safieddine, S., Bouleau, Y., Schneggenburger, R., Chapman, E. R., Petit, C., and Dulon, D. (2010). Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J. Neuroscience 30, 13281-13290.

Xiao L., Han Y., Runne H., Murray H., Kochubey O., Lüthi-Carter R. and Schneggenburger R. (2010) Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons. Mol Cell Neurosci 44: 374-85.

Müller, M., Goutman, J., Kochubey O., Schneggenburger R. (2010) Interaction between facilitation and depression at a large CNS synapse reveals mechanisms of short-term plasticity. J. Neuroscience, 30: 2007 - 2016.

Kochubey, A., Han, Y. Schneggenburger, R. (2009) Developmental regulation of the intracellular Ca2+ sensivity of vesicle fusion and Ca2+ - secretion coupling at the rat calyx of Held J. Physiology, 587: 3009 -3023.

Müller, M., Felmy, F., Schneggenburger, R. (2008) A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held. J. Physiology 586: 5503 - 5520.

Lou, X., Korogod, N., Brose, N., Schneggenburger, R. (2008) Phorbol esters modulate spontaneous and Ca2+ -evoked transmitter release via acting on both Munc13 and protein kinase C. J. Neuroscience 28: 8257- 8267.

Korogod, N., Lou, X., Schneggenburger, R. (2007) Posttetanic potentiation critically depends on an enhanced Ca2+ sensitivity of vesicle fusion mediated by presynaptic PKC. Proc. Natl. Acad. Sci. USA 104: 15923-15928.

Wölfel, M., Lou, X., Schneggenburger, R. (2007) A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse J. Neuroscience 27: 3198-3210.

Müller, M., Felmy, F., Schwaller, B., Schneggenburger, R. (2007) Parvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of Held that accelerates the decay of Ca2+ and short-term facilitation. J. Neuroscience 27 : 2261-2271.