Our group is interested in the genetic mechanisms behind the emergence of higher cognitive function during later stage of development/maturation of the nervous system. The proposed project entails a collaboration between Karolinska Institutet, MIT and SciLife Laboratories. It aims at developing state of the art molecular techniques to utilize the CRISPR/Cas9 system to, in a cell specific manner, influence neuronal gene expression in vivo. We will use the established large scale single cell analysis (RNA-seq and In Situ sequencing), and electrophysiology to assay the effect of the manipulations.
We are seeking a highly motivated person with a PhD in molecular biology with at least one first authorship publication. Priority will be given to applicants with experience in working with molecular tools such as CRISPR or virus production.
The laboratory is situated in the division of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet, which is an extremely dynamic and vibrant scientific environment with state of the art equipment available.
The position is funded by stipends for 2 years and the candidate is encouraged
to apply for independent funding during this period.