Dr. Ira Milosevic European Neuroscience Institute, Göttingen – European Neuroscience Institute, Göttingen

  • Young Investigator

Synaptic Vesicle Dynamics

  • European Neuroscience Institute, Göttingen
  • [email protected]
  • +49 551 39 12379
  • +49 551 39 12346
  • Germany

About Dr. Ira Milosevic

We are interested in the fundamental aspects of synaptic vesicle recycling that have relevance to neurological and neurodegenerative diseases, using mammalian cells and mice as model systems. My research group combines the cutting edge genomic engineering with the latest techniques of imaging and cell biology to study the processes that regulate synaptic vesicle formation. In a distinct but related line of work we are exploring the signaling processes that originate from altered neurotransmission and lead to neurodegeneration.

Please see also: http://www.eni.gwdg.de/index.php?id=374

5 Selected Publications

Giordano F., Saheki Y., Idevall-Hagren O., Colombo SF., Pirruccello M., Milosevic I., Gracheva EO., Bagriantsev SN., Borgese N., De Camilli P. (2013) PI(4,5)P2-dependent and Ca2+-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell, 153 (7) : 1494-509.

Soda K., Balkin DM., Ferguson SM., Paradise S., Milosevic I., Giovedi S., Volpicelli-Daley L., Tian X., Wu Y., Ma H., Son SH., Zheng R., Moeckel G., Cremona O., Holzman LB., De Camilli P., Ishibe S. (2012) Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin. Invest., 122 (12) : 4401-11.

Milosevic I., Giovedi S., Lou X., Raimondi A., Collesi C., Shen H., Paradise S., O’Toole E., Ferguson S., Cremona O., De Camilli P. (2011) Recruitment of endophilin to clathrin coated pit necks is required for efficient vesicle uncoating after fission. Neuron., 72 (4) : 587-601.

de Wit H., Walter A., Milosevic I., Gulyás-Kovács A., Sørensen JB., Verhage M. (2009) Four proteins that dock secretory vesicles to the target membrane. Cell, 138 (5) : 935-96.

Milosevic I., Sørensen JB., Lang T., Krauss M., Nagy G., Haucke V., Jahn R., Neher E. (2005) Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci., 25 (10) : 2557-65.


Fellowships, Awards and Honours

2013                Emmy Noether/DFG Young Investigator Award
2011                Federation of European Biochemical Societies (FEBS) Anniversary Prize
2011                Epilepsy Foundation Fellowship
2010                Society of Neuroscience (SfN) Travel Award
2007                European Molecular Biology Organization (EMBO) Postdoctoral Fellowship
2006                International Max Planck Research Schools (IMPRS) Fellowship
2003                Boehringer Ingelheim Fond (B.I.F.) Fellowship
2001                DeveloGen Scholarship
2000                Chancellor’s Award for the Year 2000, Croatia
1998                Croatian Ministry of Science and Education Scholarship for Gifted Students

Technical Expertise

  • Cell biology
  • Advanced imaging
  • Electrophysiology
  • Biochemistry
  • Mouse genetics
  • Super-resolution microscopy at the synapse
  • Phosphatidylinositol signalling
  • Early and late signs of neurodegeneration changes
  • Regulation of synaptic transmission