Rhythmic neuronal activity reflects the coordination and interactions of networks of neurons during complex cognitive processes and behaviour. Accordingly, many psychiatric disorders are associated with impaired neural synchrony.
We use specialized electrode arrays to record simultaneously from large groups of neurons, measuring synchrony of network activities in anatomically and functionally related circuits, both during normal behaviour and in models of diseases like schizophrenia, Down syndrome and Alzheimer´s Disease.
Witton J.*, Padmashri R.*, Zinyuk L.E.*, Popov V.I., Kraev I., Line S.J., Jensen T.P., Tedoldi A., Cummings D., Tybulewicz V.L.J., Fisher E.M.C., Bannerman, D.M., Randall A.D., Brown J.T., Edwards F.A., Rusakov D.A., Stewart M.G. and Jones M.W. (2015) Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neurosci. 18: 1291-8
Gardner R.J., Hughes S.W. and Jones M.W. (2013) Differential spike timing and phase dynamics of reticular thalamic and prefrontal cortical neuronal populations during sleep spindles. J. Neurosci. 33: 18469-80
Phillips K.G.*, Bartsch U.*, McCarthy A.P., Edgar D.M., Tricklebank M.D., Wafford K.A. and Jones M.W. (2012) Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia. Neuron 76: 526-33
McHugh T., Jones M., Quinn J., Balthasar N., Coppari R., Elmquist J., Lowell B., Fanselow M., Wilson M., and Tonegawa S. (2007) Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network. Science, 317 (5834): 94-9.
Jones M., and Wilson M. (2005) Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task. PLoS Biol., 3 (12): e402.
2013Member of the Wellcome Trust Expert Review Group for Cellular and Molecular Neuroscience
2012Member of MRC Industrial Collaborative Training and Careers (ICTC) Assessment Panel
2011MRC Senior Non-clinical Fellowship (till '16)
2006RCUK Academic Fellowship (till '11)
2006Integrative Pharmacology Fund Fellowship (till '11)
2000Wellcome Trust International Prize Travelling Fellowship (till '02)
1993Scholar of Sidney Sussex College, Cambridge (for 1st Class B.A. in Natural Sciences)