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Institut Pasteur
25-28 rue du Docteur Rous

75015 - Paris

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Dr Bernhard Lakowski
The European Neuroscience Insitute in Paris, Pasteur

Research Area

This group is using genetic approaches in the nematode Caenorhabditis elegans to understand better the function and biological role of an important class of proteins.
In C.elegans, five spr genes (for suppressor of presenilin) have been identified that bypass the need for one presenilin gene, sel-12, by de-repressing the transcription of a second presenilin gene, hop-1.
The group studies the biological and biochemical roles of the SPR proteins and looks for additional factors that can modify the phenotypes of presenilin mutants in C.elegans.

B. Lakowski , S. Eimer, C. Göbel, A. Böttcher, B. Wagler and R. Baumeister(2003):Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans..Development:2117-2128.
Eimer S, Lakowski B, Donhauser R, Baumeister R. (2002):Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1..EMBO J.:Nov 1;21(21):5787-96.
N. Wittenburg, S. Eimer, B. Lakowski, Sascha Röhrig, Claudia Rudolph and Ralf Bau meister(2000):Presenilin is required for proper morphology and function of neurons in C..elegans. Nature:306-309.

Technical Expertise