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Karolinska Institutet
Stockholm Nobel Institute for Neurophysiology
Department Neuroscience

17177 - Stockholm


Job opportunities

Dr Oleg Shupliakov
Neuronal Membrane Trafficking and Synaptic Transmission
The European Neuroscience Institute at Karolinska Institutet, Stockholm

Research Area

The research goal of the group is to clarify molecular mechanisms controlling the formation of clathrin-coated vesicles at the plasma membrane, with a focus on neuronal cells.
This includes mechanisms, which control the organization of endocytic sites and mechanisms of fission of vesicles from the plasma membrane (experiments are focused on the role of interactions of dynamin-binding accessory proteins).
These processes are of general importance for cell function and development.
Breakdown of receptor deactivation mechanisms may lead to cancer.
Decreased expression of endocytic proteins in neurons is observed in patients with schizophrenia and Alszheimer‘s disease.

Shupliakov, O. , Bloom, O., Gustafsson, J.S, Löw, P., Kjaerulff, O., Tomilin, N., Pieri bone, V., Greengard, P., Brodin, L(2002):Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton..Proc. Natl. Acad. Sci:14476-14481
Gad, H., Löw, P., Zotova E., Brodin, L., Shupliakov, O(1998):Dissociation between Ca2+-triggered synaptic vesicle exocytosis and clathrin-mediated endocytosis in a central synapse..Neuron:607-616

Technical Expertise