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The Institute of Experimental Medicine ASCR in Prague
Academy of Sciences of the Czech Republic
Department of Tissue Culture and Stem Cells
Videnská 1083
142 20 Prague 4 - Prague
Czech Republic

+420 296 442 828
+420 296 442 706

Job opportunities

Dr Pavla Jendelova
Neurotransplantation and repair
The Institute of Experimental Medicine ASCR in Prague

Research Area

The group’s studies are aimed at exploring the potential use of cell therapy to repair and improve the biological functioning of defective nervous tissue.
Research focuses on the labeling and in vitro differentiation of different types of stem cells (bone marrow, olfactory, induced pluripotent, neural), the transplantation of these cell types into the injured CNS, the use of magnetic resonance imaging to track superparamagnetic nanoparticlelabeled cells post-implantation, and the use of biopolymer hydrogels to bridge spinal cord lesions and promote tissue regeneration.

Jendelová, P., Herynek, V., De Cross, J., Glogarová, K., Andersson, B., Hájek, M., Syková, E.: (2003) Imaging the fate of implanted bone marrow stromal cells labeled with superparamagnetic nanoparticles. Magn Reson Med. 50(4): 767-776.

Hudson, J.E., Chen, N., Song, S., Walczak, P., Jendelová, P., Syková, E., Wiling, A.E., Saporta, S., Bickford, P., Sanchez-Ramos, J., Zigova, T.: (2004) Green fluorescent protein bone marrow cells express hematopoietic and neural antigens in culture and migrate within the neonatal rat brain.J.Neurosci. Res.76: 255-264

Jendelová, P., Herynek, V., Urdzíková, L., Glogarová, K., Kroupová, J., Bryja, V., Andersson, B., Burian, M., Hájek, M., Syková, E.: (2004) MR tracking of transplanted bone marrow and embryonal stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J. Neurosci. Res. 76: 232-243.

Jendelova, P., Herynek, V., Urdzikova, L., Glogarova, K., Rahmatova, S., Fales, I., Andresson, B., Procházka, P., Zamecnik, J., Eckschlager, T., Kobylka, P., Hajek, M., Sykova, E., (2005) MR Tracking of  CD34+ progenitor cells separated by means of immunomagnetic selection and transplanted into injured rat brain. Cell Transplant.14: 173-182

Sykova, E and Jendelova P., (2005) Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann. N.Y.Acad. SCi. 1049: 146-160

Syková, E., Jendelová, P., (2006) Magnetic resonance tracking of transplanted stem cells in rat brain and spinal cord. Neurodegenerative Diseases 3(1-2):62-77.

Urdzíková, L., Jendelová, P., Glogarová, K., Burian, M., Hájek, M., Syková, E. (2006). Transplantation of bone marrow stem cells as well as mobilization by granulocyte - colony stimulating factor promote recovery after spinal cord injury in rat. J. Neurotrauma23(9):1379-1391.

Sykova E, Jendelova P. Migration, fate and in vivo imaging of adult stem cells in the CNS. Cell Death Differ. 2007 Jul;14(7):1336-42. Review.

Horak D, Babic M, Jendelova P, Herynek V, Trchova M, Pientka Z, Pollert E, Hajek M, Sykova E. D-mannose-modified iron oxide nanoparticles for stem cell labeling. Bioconjug Chem. 2007 May-Jun;18(3):635-44.

Hejčl A, Urdzíková L, Šedý J, Lesný P, Přádný M, Michálek J, Burian M, Hájek M, Zámečník J, Jendelová P, Syková E. () Acute and delayed implantation of positively charged HEMA scaffolds in spinal cord injury in the rat. J Neurosurg - Spine2008; 8 (1), 67-73.

Babic M, Horák D, Trchová M, Jendelová P, Glogarová K, Lesný P, Herynek V, Hájek M, Syková E.Poly(l-lysine)-Modified Iron Oxide Nanoparticles for Stem Cell Labeling. Bioconjug Chem. 2008 Mar;19(3):740-50

Turnovcová, K., Rů�ičková, K., Vaněček V., Syková, E., Jendelová, P. Properties and growth of human bone marrow mesenchymal stromal cells cultivated in differentmedia. Cytotherapy 2009; 11(7):874-85.
Hejčl A, Šedý J,  Kapcalová M, Arboleda Toro D, Amemori T, Lesný P, Likavčanová K, Burian M, Krumbholcová E, Přádný M, Michálek J, Hájek M, Jendelová P, Syková E, HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. Development Stem Cells Dev. 2010 Oct;19(10):1535-46.

Amemori T, Jendelová P.,  Rů�ičková K,Arboleda Toro D, , Syková E. Olfactory ensheathing glia and mesenchymal stromal cells improve locomotor function after spinal cord injury in the rat, but co-transplantation does not have synergistic effects Cytotherapy, April 2010, Vol. 12, No. 2, Pages 212-225.

Seminatore, C., Polentes, J., Ellman D., Kozubenko, N., Itier, V., Tine, S., Tritschler, L., Brenot, M., Guidou, E., Blondeau, J., Lhuillier, M., Bugi, A., Aubry, L., Jendelova, P., Sykova, E., Perrier, A.L., Finsen, B, Onteniente, B. The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors. Stroke, 2010 Jan;41(1):153-9.

Kozubenko N, Turnovcova K, Kapcalova M, Butenko O, Anderova M, Rusnakova V, Kubista M, Hampl A, Jendelova P, Sykova E. Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors. Cell Transplant. 2010 Vol. 19 pp. 471–486. 

Kotková Z, Kotek J, Jirák D, Jendelová P, Berková Z, Hermann P, Lukeš I Cyclodextrin-based Bimodal Fluorescence/MRI Contrast Agents: an Efficient Approach to Cellular Imaging Chemistry. 2010 Sep 3;16(33):10094-102

Urdziková L, Likavčanová-Mašínová K, Vaněček V, Rů�ička J, Sedý J, Syková E, Jendelová P. Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat. Cytotherapy. 2011 Oct;13(9):1090-104.
Arboleda D, Forostyak S, Jendelova P, Marekova D, Amemori T, Pivonkova H, Masinova K, Sykova E. Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury. Cell Mol Neurobiol. 2011 31( 7):1113-1122
Řehoř I, Vilímová V, Jendelová P, Kubíček V, Jirák D, Herynek V, Kapcalová M, Kotek J, Černý J, Hermann P, Lukeš I. Phosphonate-titanium dioxide assemblies: platform for multimodal diagnostic-therapeutic nanoprobes. J Med Chem. 2011 Jul 28;54(14):5185-94.

Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E. Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. Cytotherapy. 2011 Oct;13(9):1036-46.

Novotna B, Jendelova P, Kapcalova M, Rossner Jr. P, Turnovcova K, Bagryantseva Y, Babic M, Horak D, Sykova E. Oxidative damage to biological macromolecules in human bone marrow mesenchymal stromal cells labeled with various types of iron oxide nanoparticles. Toxicology Letters, 2012

Technical Expertise

cell culture
seeding cells on biomaterials
animal models of SCI, stroke, ALS, AD
behavioral tests