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Institut Pasteur
25 rue du Docteur Rous
Receptors and Cognition Laboratory URA CNRS 2182
Cedex 15
75724 - Paris

+33 1 40 61 31 02
+33 1 45 68 83 69

Job opportunities

Dr Pierre-Jean Corringer
Molecular Biology
The European Neuroscience Insitute in Paris, Pasteur

Research Area

This group aims to identify the molecular and cellular processes governing nicotinic cetylcholine receptor function in the brain and at the periphery.
Research is also focused on the effect of nicotine as a drug of addiction on these processes.
The multidisciplinary approach includes immunoprecipitation and imaging techniques to monitor receptor maturation and targeting.
Protein overproduction for X-ray crystallography, as well as mutagenesis coupled to functional, electrophysiological, and molecular modeling is used to assess the receptor structure and the nature of its allosteric transitions following agonist exposure.
The work also aims at developing specific ligands, that will be valuable for the treatment of pathologies, including tobacco addiction and Alzheimer disease.

Bocquet, N., Prado de Carvalho, L., Cartaud, J., Neyton, J., Le Poupon, C., Taly, A., Grutter, T., Changeux, J.P., Corringer, P.J. (2007):A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family..Nature:445:116-119.
Sallette J., Bohler S., Benoit P., Soudant M., Pons S., Le Novere N., Changeux J.P., Corringer P.J(2004):An extracellular microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine..J. Biol. Chem:18767-75
Corringer, P.J. , Bertrand, S, Galzi, J.L., Devillers-Thiéry, A., Changeux J.P. and Bertrand, D(1999):Mutational analysis of the charge selectivity filter of the alpha7 nico tinic acetylcholine receptor..Neuron:831-843

Technical Expertise