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European Neuroscience Institute Göttingen
Developmental Neurobiology
Grisebachstr. 5

37077 - Göttingen

+49 551 39-13400
+49 551 39-9843

Job opportunities

Dr Till Marquardt
European Neuroscience Institute, Göttingen

Research Area

My team utilizes a combination of molecular genetic and cell biological approaches, combined with transcriptomics and electrophysiology to explore molecular pathways operating in the assembly, plasticity and vulnerability of the spinal neuromuscular circuitry.


Wang, L. and Marquardt, T. (2012). Live monitoring of heterotypic axonal interactions in vitro. Nature Protocols In Press.

Bonanomi, D., Chivatakarn, O., Bai, G., Lettieri, K., Abdesselem, H., Marquardt, T., Pierchala, B.A., and Pfaff, S.L. (2012). Ret is a multifunctional co-receptor that integrates diffusible- and contact-axon guidance signals. Cell In Press.

Wang, L., Klein, R., Zheng, B., and Marquardt, T. (2011). Anatomical coupling of sensory and motor nerve trajectory through axon tracking. Neuron 71: 263-277.

Voigt, A., Herholz, A., Fiesel, F.C., Kaur, K., Müller, D., Karsten, P., Kahle, P.J., Marquardt. T.1 and Schulz, J.B.1 (2010). TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS One 5(8): e12247.1(co-corresponding authors)

Ghosh, S., Marquardt, T., Thaler, J., Carter, N., Pfaff, S.L. and Hunter, T. (2008). Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors. Proc. Natl. Acad. Sci. USA 105: 335-40.

Oron-Karny, V., Farhy, C., Elgart, M., Marquardt, T., Remizova, L., Yaron, O., Xie, Q., Cvekl, A., and Ashery-Padan. R. (2008). Dual role of Pax6 within two distinct retinal progenitor cell pools. Development 135: 4037-47.

Gallarda, B., Bonanomi, D., Müller, D., Brown, A., Alaynick, W.A., Lemke, G., Pfaff, S.L, and Marquardt, T. (2008). Segregation of axial sensory and motor pathways through heterotypic trans-axonal signaling. Science 320: 233-236.

Bassett, E.A., Pontoriero, G.F., Feng, W., Marquardt T., Fini, M.E., Williams, T., West-Mays, J.A. (2007). Conditional Deletion of AP-2(alpha) in the Developing Retina Demonstrates Non-Cell Autonomous Roles for AP-2{alpha} in Optic Cup Development. Molecular and Cellular Biology 27: 7497-510.

Xu S., Sunderland M.E., Coles B.L., Kam A., Holowacz T., Ashery-Padan R., Marquardt T., McInnes R.R., van der Kooy D. (2007). The proliferation and expansion of retinal stem cells require functional Pax6. Developmental Biology 304,713-21.

Yaron, O., Farhy, C., Marquardt, T., Applebury, M., Ashery-Padan, R. (2006). Notch1 inhibits premature photoreceptor specification in the mouse retina. Development 133, 1367-1378.

Marquardt, T., Shirasaki, R., Ghosh, S., Carter, N., Andrews, S.E., Hunter, T., and Pfaff, S.L. (2005). Co-expressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane sub-domains. Cell 121, 127-139.

Davis-Silberman, N., Kalich, T., Oron-Karni, V., Marquardt, T., Zillig, M., Tamm, E. R. and Ashery-Padan, R. (2005). Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Human Molecular Genetics 14, 2265-2276.

Ashery-Padan, R., Xhu, X.L., Marquardt, T., Herrea, P., Berry, A., Gruss, P. (2004). Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Developmental Biology 269, 479-488.

Bäumer, N., Marquardt, T., Stoykova, A., Treichel, D., and Ashery-Padan, R., Gruss, P. (2003). Retinal Pigment Epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130, 2903-2915.

Bäumer, N.2, Marquardt, T.2, Stoykova, A., Ashery-Padan, R., Chowdhury, K., and Gruss, P. (2002). Pax6 is required for the establishment of nasotemporal and dorsal characteristics of the retina. Development 129, 4535-4545. 2(equally contributing authors).

Marquardt, T., Ashery-Padan, R.A., Andrejewski, N., Scardigli, R., Guillemot, F., and Gruss, P. (2001). Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43-55.

Ashery-Padan, R.A., Marquardt, T., Zhou, X., and Gruss, P. (2000). Pax6 activity in the lens primordium is required for lens formation and the correct placement of a single retina in the eye. Genes & Development 14, 2701-2711.

Review articles and book chapters:

Marquardt, T., and Gruss, P. (2003). Molecular genetic approaches in the study of retinal progenitor cells and stem cells. In: Stem Cells Handbook, Humana Press, Totowa-NJ.

Marquardt, T. (2003). Transcriptional control of neuronal diversification in the retina. Progress in Retinal and Eye Research  22, 567-577. (IF: 8.5).

Marquardt, T., and Gruss, P. (2002). Generating neuronal diversity in the retina: one for nearly all. Trends in Neuroscience 25, 32-38. (IF: 14.4).

Marquardt, T., and Pfaff, S.L. (2001). Cracking the transcriptional code for cell specification in the neural tube. Cell 106, 651-654. (IF: 32.4)

Technical Expertise

mouse molecular genetics,

neuromuscular conditioning paradigms

anatomical circuit tracing

single-neuron laser-capture microdissection and transcriptomics

whole cell patch clamp recordings on acute spinal cord slices

live neuron/axon spinning-disk microscopy complemented by rapid transposon-based in vivo-gene manipulation in chick