Christophe Mulle studied at the Ecole Normale Supérieure in Cachan. He is a cellular neurobiologist expert in electrophysiology of synaptic transmission and glutamate receptors. After a PhD at the Pasteur Institute with Jean-Pierre Changeux and a post-doc at the Salk Institute with Steve Heinemann, he has been guiding a CNRS laboratory in Bordeaux since 1995. His research ambitions to link cell biological mechanisms of protein trafficking to synaptic physiology and to address synaptic dysfunction in models of cognitive disorders such as Alzheimer's disease. He has contributed to the understanding of the elusive kainate receptors as regulators of neural circuits and provided the first insights into the molecular events that govern their polarized trafficking. In recent years he has investigated the mechanisms of synaptic integration and plasticity in hippocampal CA3 pyramidal cells. A unique strength of his team is its ability to implement interdisciplinary studies, bridging molecular and cellular techniques to physiological questions in vitro, and in vivo in the context of episodic memory encoding.
The projects of the team are centered on the formation, operation and plasticity of cortical circuits involved in rapid memory encoding. The group has two main focuses, 1) the mechanisms underlying the specification and plasticity of synaptic properties in hippocampal pyramidal cells and 2) the operation and plasticity of local cortical circuits (mainly CA3) in the context of episodic-like memory encoding. Great efforts are made to implement these questions at an integrated level in the mouse and to develop methods for interrogating the connectivity and function of local circuits in vivo in behavioural conditions. These studies address control conditions as well as mouse models of cognitive disorders such as Alzheimer's disease.
The group uses a combination of approaches including the development and application of cell-specific gene targeting, in vitro and in vivo electrophysiology, cell biology, live cellular imaging, neural circuit mapping, neurocomputation and behaviour.
For further information, please also see: http://www.iins.u-bordeaux2.fr/research-teams/mulle and http://www.inb.u-bordeaux2.fr/dev/EN/researcher.php?researcher=Christophe%20Mulle&id=103
A full publication record can be found here.