Dr. Ines Araujo Regenerative Medicine Program – The Center for Neuroscience and Cell Biology (CNC) Coimbra

  • Young Investigator

Neurodegeneration and Injury-Induced Neurogenesis

  • Regenerative Medicine Program
  • [email protected]
  • +351-289 800094-7534
  • +351 289 800076
  • Portugal

About Dr. Ines Araujo

Brain injury is characterized by neuronal loss and dysfunction, accompanied by neuroinflammation and an upregulation of the formation of new neurons (neurogenesis). Nevertheless, the phenomena of Injury-induced neurogenesis is far from being efficient. In our group, we are interested in understanding how the inflammatory microenvironment of the brain regulates the neurogenic response. Establishing the mechanisms by which inflammatory factors influence the formation of new neurons after injury will help in the identification of new strategies to repair the damaged brain.

For more information, please also see: http://cbmr.ualg.pt/research/stemcelldevelop/inesaraujo/

5 Selected Publications

Carreira BP, Morte MI, Santos AI, Lourenço AS, Ambrósio AF, Carvalho CM, Araújo IM (2014) Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling. Frontiers in Cellular Neuroscience 8: 343.

Martinez-Ruiz A., Araújo IM., Izquierdo-Álvarez A., Hernansanz-Agustín P., Lamas S., Serrador JM. (2013) Specificity in S-nitrosylation: a short-range mechanism for NO signaling? Antioxid. Redox Signal, 19 (11) : 1220-35.

Carreira BP., Morte MI., Lourenço AS., Santos AI., Inácio Â., Ambrósio AF., Carvalho CM., Araújo IM. (2013) Differential contribution of the guanylyl cyclase-cyclic GMP-Protein kinase G pathway to the proliferation of neural stem cells stimulated by nitric oxide. Neurosignals, 21(1-2): 1-13.

Carreira BP., Carvalho CM., Araújo IM. (2012) Regulation of injury-induced neurogenesis by nitric oxide. Stem Cells Int., 2012:895659.

Carreira BP., Morte MI., Inácio Â., Rosmaninho-Salgado J., Costa G., Agasse F., Carmo A., Couceiro P., Brundin P., Ambrósio AF., Carvalho CM., Araújo IM. (2010) Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor. Stem Cells, 28 (7) : 1219-1230. 

Awards, Fellowships and Honours

2011            PI, “iCALP-Identification of the physiological roles of calpains in the control of cell proliferation and migration in the CNS", FCT
2005            Medal of Honour L´Oréal Portugal for Women in Science
2004            Postdoc Fellowship, Portuguese Science and Technology Foundation
2003            Short-Term Fellowship, FEBS
2000            Ph.D. Fellowship, Portuguese Science and Technology Foundation

Technical Expertise

  • Adult neurogenesis
  • Stem cells
  • Brain repair
  • Neuroinflammation
  • Glutamate receptor-mediated excitotoxcity in the hippomcampus
  • Proteases involved in neurotoxicity
  • In Vitro and In Vivo models for neurodegeneration
  • Brain ischemia
  • Laser scanning microscopy
  • Time-lapse imaging (intracellular recordings and cellular migration)
  • CNS histology
  • Primary cell cultures (hippocampal neurons, retinal cells, subventricular zone cells, astrocytes, microglia)