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Laboratory of Neuromodulation and Metabolism
Largo Marquês de Pombal

3004-517 - Coimbra

+351 239 820-190 or -126

Job opportunities

Dr Attila Kofalvi
Neuromoduluation, Metabolism
The Center for Neuroscience and Cell Biology (CNC) Coimbra

Research Area

Our mission is to explore the alterations of neuronal communication and the impairment of brain´s glucose metabolism in neurological and psychiatric disorders, such as Alzheimer´s and Parkinson´s diseases, diabetes and schizophrenias.


5 Selected Publications

Köles L., Garção P., Zádori ZS., Ferreira SG., Pinheiro BS., da Silva-Santos CS., Ledent C., Köfalvi A. (2013) Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain. Brain Res. Bull., 97: 126-135.

Garção P., Szabó EC., Wopereis S., Castro AA., Tomé AR., Prediger RD., Cunha RA., Agostinho P., Köfalvi A. (2013) Functional interaction between presynaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. Br. J. Pharmacol., 169 (7): 1600-11.

Pandolfo P., Machado NJ., Köfalvi A., Takahashi RN., Cunha RA. (2013) Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. Eur. Neuropsychopharmacol., 23 (4): 317-28.

Richter H., Teixeira FM., Ferreira SG., Kittel Á., Köfalvi A., Sperlágh B. (2012) Presynaptic α2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat. Neuropharmacology, 63 (5): 784-97.

Ferreira SG., Teixeira FM., Garção P., Agostinho P., Ledent C., Cortes L., Mackie K., Köfalvi A. (2012) Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release – species differences. Neurochem. Int., 61 (2): 219-26


Awards, Fellowships and Honours

2009        Two national grants (PTDCSAU-OSM1056632008 and PTDCSAU-NEU1007292008)
2005        Research fellowship of the Instituto de Investigação Interdisciplinar (until 2007)
2005        Achievement award by the International Cannabinoid Research Society
2004        Post-doctoral fellowship, Fundação para a Ciência e a Tecnologia, Portuguese government (until 2007)
2004        IBRO Research fellowship
2001        Young Investigators’ Award from the Hungarian Pharmacological Society

Technical Expertise