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content/MEMBER araujo ines

Center for Neuroscience and Cell Biology
Department of Zoology
University of Coimbra

3004-517 - Coimbra
Portugal

+351 239 820190



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Dr Ines Araujo
Neurobiology
The Center for Neuroscience and Cell Biology (CNC) Coimbra

Research Area

Regulation of the proliferation of neural stem cells by nitric oxide. Neurobiology of calpains in the CNS.


Publications

BP Carreira, MI Morte, A Inácio, G Costa, J Rosmaninho-Salgado, F Agasse, A Carmo, P Couceiro, P Brundin,  AF Ambrósio, CM Carvalho, IM Araújo (2010) Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor. Stem Cells (epub May 18, 2010).

Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P, Carvalho CM (2008) Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. Journal of Neurochemistry 105(3):666-676.

 

Álvaro AR, Martins J, Araújo IM, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C. (2008) Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide. Journal of Neurochemistry 105(6):2501-2510.

 

Yu L, Shen H-Y, Coelho JE, Araújo IM, Huang Q-Y, Day Y-J, Rebola N, Canas PM, RappEK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen J-F (2008) A2A receptors modulate motor activity and MPTP neurotoxicity by distinct cellular mechanisms. Annals of Neurology 63(3):338-346.

 

Araújo IM*, Carreira BP*, Pereira T, Santos PF, Soulet D, Inácio Â, Bahr BA, Carvalho AP, Ambrósio AF, Carvalho CM (2007) Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. Cell Death and Differentiation 14(9):1635-1646.

 

Araújo IM, Ambrósio AF, Leal EC, Verdasca MJ, Malva JO, Soares-da-Silva P, Carvalho AP, Carvalho CM (2004) Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093. Epilepsia 45(12):1498-505.

 

Araújo IM, Verdasca MJ, Leal EC, Bahr BA, Ambrósio AF, Carvalho AP, Carvalho CM (2004) Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons. Journal of Neurochemistry 91(6): 1322-31.

 

 

 

 


 

 

 


Technical Expertise

laser scanning microscopy

time-lapse imaging (intracellular recordings and cellular migration)

CNS histology

primary cell cultures (hippocampal neurons, retinal cells, subventricular zone cells, astrocytes, microglia)

in vivo models of rodent epilepsy