MRC Centre for Synaptic Plasticity
School of Medical Sciences University of Bristol
Anatomy Department
University Walk
BS8 1TD - Bristol
United Kingdom

+44 117 954 6448

jon.hanley@bristol.ac.uk

Job opportunities

The control of AMPA receptor trafficking is a crucial element of synaptic plasticity and may also be important in post-ischaemic mechanisms leading to cell death.
Such trafficking is governed by protein-protein interactions with AMPA receptor subunits.
The group studies the calcium signaling and phosphorylation pathways that regulate these interactions using molecular biology, biochemistry and confocal microscopy.
This work will provide important insights into the molecular mechanisms of memory and stroke.

Hanley JG, Henley JM.(2005):PICK1 is a Calcium Sensor for NMDA-Induced AMPA Receptor Trafficking..EMBO J. 24:3266-78

Hanley J.G., Khatri L., Hanson P.I., and Ziff E.B(2002):NSF ATPase and alpha/beta SNAPs disassemble the AMPA receptor-PICK1 complex..Neuron:53-67