University of Bristol
Department of Physiology and Pharmacology
Medical Sciences Building
University Walk
BS8 1TD - Bristol
United Kingdom
+44 (0) 117 331 2276/2242
matt.jones@bristol.ac.uk
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Rhythmic neuronal activity is likely to reflect the coordination and interactions of networks of neurons during complex cognitive processes like learning and memory and decision-making.
Accordingly, many psychiatric disorders are associated with impaired neural synchrony.
We use specialized "tetrode" electrodes to record simultaneously from large groups of neurons in behaving rats and mice, measuring synchrony of network activities in anatomically and functionally related circuits, both during normal behaviour and in models of diseases like schizophrenia and Down syndrome.
Our current focus is on hippocampal-prefrontal cortical interactions during maze-based spatial learning tasks.
PublicationsMcHugh T.J.*, Jones M.W.*, Quinn J.J., Balthasar N., Coppari R., Elmquist J.K., Lowell B.B., Fanselow M.S., Wilson M.A. and Tonegawa S. (2007):Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network...Science:317:94-99. *Equal contributors
Jones M.W. and Wilson M.A. (2005):Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhytm..Hippocampus:15:867-873
Jones M.W. and Wilson M.A. (2005):Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task..PLoS Biology:3:e402.
Jones M.W., Errington M.L., French P.J., Fine A., Bliss T.V.P., Garel S., Charney P., Bozon B., Laroche S. and Davis S. (2001):A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories..Nature Neurosci.:4:289-296.
Malleret G., Haditsch U., Genoux D., Jones M.W., Bliss T.V.P., Vanhoose A.M., Weitlauf C., Kandel E.R., Winder D.G. and Mansuy I.M. (2001):Inducible and reversible enhancement of learning, memory and long-term potentiation by genetic inhibition of calcineurin..Cell:104:1-20.
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