The Nencki Institute in Warsaw
Nencki Institute of Experimantal Biology
Pasteur 3
02-093 - Warsaw
Poland
+48 22 650 3001
+48 22 822 5342
l.kaczmarek@nencki.gov.pl
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The long-term goal of our work is to understand molecular bases of persistent neuronal responses. Two sets of phenomena are under investigation: neural plasticity, including learning and memory formation, and neurodegeneration bearing features of apoptosis. Both sets of conditions share similarities in involving excitatory amino acids acting on specific receptors. Furthermore, as a result of neuronal stimulation, transduction of a signal into cell nucleus leads to activation to at least partially overlapping sets of transcription factors, and their target genes. Thus, it appears that it is not possible to understand one of these processes separately of the other.
PublicationsNagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R.M., Silva, A.J., Kaczmarek, L., Huntley, G.W. (2006):Matrix metalloproteinase (MMP-9) is required for hippocampal late-phase LTP and memory..J. Neurosci., 26:923-1934.
Frankland P.W., Bontempi B., Talton L.E., Kaczmarek L. (2004):The involvement of the anterior cingulate cortex in remote contextual fear memory..Science, 304:881-883.
Jaworski J., Mioduszewska B., Sanchez-Capelo A., Figiel I., Habas A. Gozdz A., Proszynski T. Hetman M., Mallet J., Kaczmarek L. (2003):Inducible cAMP Early Repressor, an endogenous antagonist of cAMP Responsive Element-Binding Protein, evokes neuronal apoptosis in vitro..J. Neurosci, 23:4519-4526.
Szklarczyk A., Lapinska J., Rylski M., McKay R.D.G., Kaczmarek L. (2002):Matrix metalloproteinase -9 undergoes expression and activation during dendritic remodeling in adult hippocampus..J. Neurosci., 22:920-930
Kaczmarek L., Lapinska-Dzwonek J., Szymczak S., (2002):Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections?..EMBO J., 21:6643-6648.
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