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Instituto de Biomedicina de Sevilla
Hospital U. Virgen del Rocío
Edificio IBiS, Lab 103
Avda. Manuel Siurot, s/n.
41013 - Seville



Job opportunities

Dr Ricardo Pardal
Physiopathology of neural stem cells
The Neuroscience Institute at Seville

Research Area

The objective is to study the cellular and molecular characteristics of stem cells derived from the neural crest, which give rise to the peripheral nervous system (PNS).
These cells have tremendous potential for selfrenewal and differentiation and are very attractive for their use in the treatment of neurodegenerative diseases such as Parkinson, Huntington, etc.
The laboratory is focusing on a specific lineage of the neural crest, called the sympathoadrenal lineage, which gives rise to not only PNS neurons and glia but also to specialized neurosecretory tissue such as the adrenal medulla and the carotid body.

Pardal, R., Ortega-Sáenz, P., Durán, R., and López-Barneo, J.(2007):Glia-Like Stem Cells Sustain Physiologic Neurogenesis in the Adult Mammalian Carotid Body. Cell 131:364-377
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., and Morrison, S. J.(2006):Increasing p16Ink4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443:448-452
Molofsky, A. V., He, S., Bydon, M., Morrison, S. J., and Pardal, R.(2005):Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.Genes Dev 19:1432-1437
Molofsky, A. V., Pardal, R., and Morrison, S. J.(2004):Diverse mechanisms regulate stem cell self-renewal.Curr Opin Cell Biol 16:700-707
Pardal, R., Clarke, M. F., and Morrison, S. J.(2003):Applying the principles of stem-cell biology to cancer.Nat Rev Cancer 3:895 -902
Molofsky*, A.V., Pardal*, R., Iwashita, T., Park, I.K., Clarke, M.F., and Morrison, S.J.(2003):Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.Nature 425:962-967  *Equal contribution
Alvarez-Dolado, M., Pardal, R., Garcia-Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., and Alvarez-Buylla, A.(2003):Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.Nature 425:968-973
Iwashita, T., Kruger, G. M., Pardal, R., Kiel, M. J., and Morrison, S. J.(2003):Hirschsprung disease is linked to defects in neural crest stem cell function.Science 301:972-976
Lopez-Barneo, J., Pardal, R., and Ortega-Saenz, P.(2002):Cellular mechanism of oxygen sensing.Annu Rev Physiol 63:259-287
Pardal, R., and Lopez-Barneo, J.(2002):Low glucose-sensing cells in the carotid body.Nat Neurosci 5:197-198
Pardal, R., Ludewig, U., García-Hirschfeld, J., and López-Barneo, J.(2000):Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium.Proc Natl Acad Sci U S A 97:2361-2366

Technical Expertise

Flow cytometry and cell sorting

Confocal microscopy

Neurosphere primary cultures

Cell phate mapping with transgenic animals